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Michelle RobertsDigital Health Editor, BBC News
BbcIs it possible to become immortal using organ transplants? This was the unexpected topic of discussion this week between Chinese President Xi Jinping and Russian President Vladimir Putin when they met at a military parade in Beijing.
A translator speaking in Mandarin on behalf of Putin told SI, how human organs can be transplanted repeatedly “so that a person can become a younger and more young” despite age and can even be able to give up old age “for an indefinite period.
“It is envisaged that during this century it can be possible to live up to 150,” he added.
Their smiles and laughter suggest it’s a little poster, but can they handle something?
Organ transplants are certainly saving lives – over 100,000 people have been saved in the UK in the last 30 years, says NHS Blood and Transplant.
And continuing progress in medicine and technology mean that transplanted organs last much longer in humans.
Some patients have had a kidney transplant that has continued to work for more than 50 years.
The life of the organ depends on how healthy the donor and the recipient is – plus how well they take care of it.
For example, if you had to have a new live donor kidney, you may expect to last 20 to 25 years.
If you get it from a deceased donor, it drops to 15 to 20 years.
The type of organs also matters.
The liver can last for about 20 years, heart for 15 years and lungs nearly 10 years, According to researchS
Putin and XI can talk about being transplanted and maybe many times repeatedly.
However, the operation is a big endeavor, with significant risks. Every time you enter the knife, you roll the dice.
Currently, people receiving a new organ should also take strong rejection drugs called immunosuppressants for life. They can have side effects such as high blood pressure and increase the risk of infection.
Rejection – When your immune system begins to attack the transplanted organ because it recognizes it by coming from a different person – sometimes it can still happen, even if you are taking your medication.
Scientists are working on the creation of organs without rejection, using genetically changed pigs as donors.
They use a gene editing tool that they know as CRISPR to remove some of the pork genes and add certain human genes to make the organ more compatible.
Breeding special pigs for this is ideal, say experts, as their organs are approximately the right size for humans.
Science is still extremely experimental, but heart and kidney The operation moved on.
The two men who agreed to have the procedures were the pioneers of this new field of transplantation.
Both have died since then, but have helped promote xenotransplantation – the transplantation of living cells, tissues or organs from one species to another.
Another avenue that is being studied is the cultivation of brand new organs using our own human cells.
Stem cells have the ability to grow into any type of cell or tissue found in the body.
No research group has yet been able to make fully functional, transplants human organs, but scientists are approaching.
In December 2020, the UKL researchers and the Francis Creek Institute restore human thymus, a major organ in the immune system – using human stem cells and bio -engineered scaffolding.
When transplanted into mice as a test, it seems to work.
And scientists at the Great Ormond Street Hospital in London say they have grown intestinal grafts using a patient tissue stem cells that could one day lead to personalized transplants for children with intestinal insufficiency.
But these achievements are for the treatment of poor health, instead of keeping people alive up to 150.
Bloomberg through Getty ImagesMeanwhile, technology entrepreneur Brian Johnson spends millions a year trying to reduce his biological age.
He is not yet trying to obtain new organs – as far as we know – but he has been in the plasma of his 17 -year -old son.
Since then, he has stopped this after seeing no benefits and increased medical control from organizations such as Food and Medicines Administration.
Dr. Julian Muts of King’s College London said beyond the transplantation of organs, approaches such as plasma replacement are examined, but they remain experimental.
“Whether such strategies will have a significant impact on life, especially the maximum life, remains uncertain, although it is an area with considerable scientific interest.”
Prof. Neil Mabbot, an immunopathology expert at the Roslin Institute, the University of Edinburgh, speculates that life at 125 can be the upper limit.
“The most arrogant living man was French, Jeanne Calment, who lived for 122 years, between 1875 and 1997,” he told the BBC News.
Ghetto imagesAnd while damaged and diseased organs can be removable by transplants, as we grow older our bodies become much smaller or can handle physical stressors.
“We begin to react less effectively to infections. Our bodies become more fragile, prone to injuries and are less capable of recovering and repairing.
“The stress, trauma and effects of transplant surgery, along with the prolonged use of immunosuppressive drugs needed to prevent the rejection of transplanted organs, would be too severe in patients with such advanced age.”
He says that instead of focusing on extending life expectancy, we should instead strive for the living years of life.
Prof. Mabbot said: “Living much longer, but suffering from the multiple incidence that can accompany aging, and get involved and go to hospital for another tissue transplant, it doesn’t sound an attractive way to spend my retirement!”