Crispr Offers New Hope for Treating Diabetes

CRISPR gene-editing technology Has shown its revolutionary possibilities in recent years: it has been used Treat the rare diseaseFrom Adapt to the crop To prevent the ultimateness of climate change, or even Change the color A spider web. However the biggest hope it is This technology Will help seek the cure for such a global disease DiabetesThe Indicates a new study in that direction.

For the first time, researchers have succeeded in planting the CRISPR-edited pancreatic cells in a person with type 1 diabetes, an autoimmune disease where the resistance attacks the inseulin producing cells in the pancreas. Without insulin, the body is unable to control blood sugar. If steps are not taken to handle glucose layers in other ways (usually with insulin injection), it can cause damage to nerves and organs – especially the heart, kidney and eyes. About 9.5 million people worldwide have type 1 diabetes.

In this experiment, the cells produced insulin for months after transplanting, without the need to take any immunospaceful drugs to stop attacking any immunoseptic drugs in cells. CRISPR technology researchers avoided the detection of camouflaged genetically changed cells.

Study, published last month New England Journal of Medicine, Step -by -step method details. First, the pancreatic islet cells were taken from a dead donor without diabetes, and then the gene-editing technique was changed by CRISPR-Cass 12B so that they allow the diabetes patient to prevent the patient’s resistance. The modified rooms are called “hypimmune”, a professor at Cedar’s-Sinai Medical Center in California and the scientific cofounder of Sana Biotechnology, who created this treatment, explains Sonja Shipfar.

The edited cells were then planted on the front muscles of the patient and no symptoms of rejection were detected after 12 weeks. (A Next report Sana Biotechnology is mentioned that implanted cells are still avoiding the patient’s prevention system after six months))

As part of the study, the cells were effective: the cells were effective: implanted cells hidden insulin as a glucose level, representing the original step towards the control of diabetes without the need for insulin injections. Four hostile events were recorded during follow-up with the patient, but none of them were directly associated with serious or changed cells.

The ultimate goal of the researchers is to apply immune-camoflageing gene edits to stem cells-which the body has the ability to reproduce and distinguish itself in other cells in the body-and then to manage their development into insulin-sequating islet cells. “The benefit of engineering hypoimmune stem cells is when these stem cells are when new cells extend and produce new cells, new cells are also hypimmune,” explained in Shipfar A Cedars-Sinai Q+A Early this year.

DITION TEARS, in order to replace foreign cells into the patient, the patient’s resistance system needs to be suppressed to avoid rejecting them. It carries significant risks: infection, toxicity and long -term complications. “Patients were disappointed to see the death of patients or severe complications from immunospration, and I decided to focus on developing the resistance to deny the resistance of the resistance without immunosopressive drugs,” I have decided to develop my career, “

Although the research has identified a milestone in search for the treatment of Type 1 diabetes, it is important to note that a participant involves a participant who received less dose of cells for a short time – does not need to control their blood sugar with the patient and injection insulin. An editorial by the journal Nature It also said that some independent research groups failed in their efforts to confirm that the Sanar method provided the ability to avoid the prevention cells.

Sana will want to manage more clinical trials starting next year. The possibility of replacing revised cells to disappear in the resistance system, without criticizing the current study and limits, opens up a very promising horizon in the regenerative drug.

This story was originally attended Wired In Spanish And have been translated from Spanish.