“Incomparably” snake anti -aneven made by a bite by a person 200 times

The blood of an American man, who has deliberately injected with a snake poison for nearly two decades, has led to an “incomparable” anti -ainterium, scientists say.

The antibodies found in the blood of Tim Fride have been shown to protect against fatal doses of a wide range of species in animal tests.

These therapies must correspond to the specific types of poisonous snake from which someone has been bitten.

But the 18 -year mission of the Fride can be a significant step in finding a universal antidone against all snakes -who kill up to 140,000 people a year and leave three times more than many who need amputations or confronted disability.

In total, Fride has maintained more than 200 bites and more than 700 poison injections, which he prepared from some of the most memorable snakes in the world, including many types of momby, cobra, taepani and ends.

Initially, he wanted to build his immunity to defend himself when he handles snakes, documenting his feats on YouTube.

But the former truck mechanic said he “completely fucked” early when two cobra bite in a quick order left him in a coma.

“I didn’t want to die. I didn’t want to lose my finger. I didn’t want to miss work,” he told the BBC.

The motivation of G -n Fride was to develop better therapies for the rest of the world, explaining: “I just turned into a way of life and I just continued to press and press and press as hard as I can press -for people who are 8,000 miles from me who die from the snake.”

Currently Antevenom is done by injecting small doses of snoop poison into animals, such as horses. Their immune system fights the poison by producing antibodies and they are collected to be used as therapy.

But Venom and Antyvenom must be combined as toxins in poisonous bite range from one species to another.

There is even a great variety within the same species – Antenom made by snakes in India is less effective Against the same species in Sri Lanka.

A team of researchers began to look for a type of immune defense called the widespread neutralization of antibodies. Instead of targeting the part of a toxin that makes it unique, they are aimed at parts that are common to whole toxins classes.

Then Jacob Glhanville, CEO of Biotech Company Centivax, came across Tim Fride.

“I was immediately like” if someone in the world has developed these widely neutralizing antibodies, it will be him “and that’s why I reached out,” he said.

“The first call, I was like” This may be uncomfortable, but I would like to get a part of your blood. “

D -Fride agreed and work received ethical approval, as the study would only take blood instead of giving it more poison.

The study focuses on the lapels – one of the two families of poisonous snakes – such as coral snakes, mammals, cobra, taepani and ends.

The lapids mostly use neurotoxins in their poison, which paralyzes their victim and is fatal when it stops the muscles needed for breathing.

Researchers have chosen 19 Laspids identified by the World Health Organization as one of the most deadly snakes on the planet. Then they began to look for the blood of the fring for protective protection.

Their work, In detail in the magazine’s cellIt identifies two widely neutralizing antibodies that can target two classes of neurotoxin. They added to a medicine that targets one -third to make their anti -eninomus cocktail.

In experiments on mice, the cocktail meant that animals survived from fatal doses of 13 of the 19 species of poisonous snake. They had partial protection against the other six.

This is an “incomparable” width of defense, according to Dr. Glangil, which said “probably covers a whole bunch of lamps, for which there is no current anti -anthuve.”

The team tries to further enhance the antibodies and see if the addition of a fourth component can lead to full protection against a lamp -snake venom.

The other class of snake – Vipers – rely more on hematoxins that attack blood rather than neurotoxins. There are a total of a dozen wide classes toxin in snake venom, which also includes cytotoxins that directly kill the cells.

“I think in the next 10 or 15 years we will have something effective against each of these toxin classes,” says Prof. Peter Quong, one of the researchers at Columbia University.

And the hunt continues in the blood samples of d -Fride.

“Tim’s antibodies are really unusual – he learned his immune system to get this very, very widespread recognition,” said Prof. Quong.

The ultimate hope is to have either an anti -antibody that can do anything, or an injection for lapids and one for Vipers.

Prof. Nick Sesswell, who is the head of the Snake Research and Interventions Center at the Liverpool School of Tropical Medicine, said the width of defense reporting was “certainly new” and provided “strong proof” that this was a real -life approach.

“There is no doubt that this work moves the field forward in an exciting direction.”

But he warned that there was a lot of work to do and that the anti -anemia still needs extensive tests before it could be used in humans.

But for the Fride, reaching this stage, “makes me feel good.”

“I do something good for humanity and it was very important to me. I’m proud of that. It’s pretty cool.”